Category: My writings

I decided to write this blog because I always have fun in trying to understand how brain perceives and retrieves information. Contrary to many of the blogs, I will not write art of literature as you can find excellent perspectives of the topic of interest in the published journals and also partly due to the paucity of time. I am penning my thoughts on what are the impending experiments one can think of doing with respect to the published work and what the future holds to give a holistic view on the topic of discussion. I tried to think, interpret and question the published work and I hope it can offer leads or hypothesis for anyone to test.

Shallow attractor basins changing the synchrony of network activity in Schizophrenia

  Schizophrenia is a complex neurocognitive disorder, which can be roughly characterised by three kinds of symptoms – positive, negative and cognitive pointing towards the heterogeneity of the disease. Neural network modelling has been used to understand the progression of the disease conditions using EEG or MEG in Schizophrenic patients. The recent article from Yuste’s…

Drafting an activity dependent law operate with neural codes shaping the network structure in an ensemble – Part II

      When and how does the excitatory and inhibitory neuron shape the ensemble to modulate a specific function during development? How does structural features of neuronal wiring influence or determine the emerging neuronal function, both at the level of single – neurons and of functional circuits? Quantifying the convergence and divergence of connectivity…

Attempts to find the causality: Genes associated with Intellectual Disabilities; SORBS2, new molecular player regulates dendritic growth and its complexity.

Dendrites can perform a gamut of operations, which involves sub-linear summation of inputs by filtering of synaptic inputs in a passive mode whilst generating supralinear spikes during active mode of information processing, there by acting as basic logical operation units (AND, OR, AND-NOT) to calculate complex operation on the incoming signals. Dendrite branching pattern and…

Transition from Academia to Industry – Mike Ehlers take

http://www.cell.com/cell/fulltext/S0092-8674(16)30553-0 Mike Ehlers departure from academia to Pfizer, when he was at the peak of his career was a major surprise to many of the neurobiologists. He was considered as one of the excellent neuronal cell biologists and his foray into industry at his young age was a shock for academics. Telling new lessons what…

Does the ensemble that shapes the function of the neuronal circuit or the individual features shapes the ensemble? Part I: Migration, Laminar allocation, synapse formation of projection and interneurons.

  One of the important questions in the field of neurosciences is to understand how the neuronal ensembles acquire physiological properties during development. In other words, how molecular and electrical properties shape the neuronal ensembles to acquire certain physiological responses during development and how they will be refined in the adult stages. It is important…

Adult brain is plastic: Re-expressing Shank3 in adult mice rescues autistic like phenotype

  Autism spectrum diseases (ASD) are associated with hundreds of genes; most of the genes that are discovered came from genome wide association studies. Whole genome wide association studies on families affected with ASD helps us in understanding the co-occurrence of SNPs (Single nucleotide polymorphism) and rare variants associated with the disease and shed light…

Return of GEVI (Genetically encoded voltage indicator): GEVI strikes back against GCaMP.

Optogenetics combined with high-resolution microscopes, which provides increase spatial resolution render neurobiologists to understand those neural circuits involved in specific functions. In other words, it let us to ask some fundamental questions on how information is processed, consolidated and retrieved by different regions of the brain. Till date, most of the optogenetics experiments to perturb…

Tame the fear or lure for extra reward: Amygdala holds the central key

Fear conditioning is a valuable behavioral paradigm for studying the neural basis of emotional learning and memory. Given that the neural circuit underlying fear conditioning as well as aversive emotional memory has been implicated in emotional disorders in humans, the molecular mechanisms of fear conditioning are potential targets of psychotherapeutic drug development. Amygdala is involved…

Nature and nurture both owns zombies in the brain; My take on neurocognitive disorders such as Autism, Schizophrenia etc. and Google’s foray into mental disorders.

In the awake of Google’s sister outfit, alphabet decided to venture into treating psychological problems such as schizophrenia Autism, bipolar disorders, depression etc. to name a few and it comes at the juncture, they managed to make a coup of recruiting Dr. Thomas Insel as the head, who will spearhead the initiative. I thought it…

Hippocampal Vs Neocortical Spines: The clash of the Titans:

                 Hippocampal Vs Neocortical Spines: The clash of the Titans: Dendritic spines are the protrusions emanating from the dendritic shaft and they act as a specialized compartment for receiving inputs from the boutons (1). They relay the information of individual inputs impinging on them by forming synapses so…

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